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Good Sofie prompts describe the job, the source, the output, and the review constraints. You do not need perfect wording. You do need enough structure for Sofie to choose the right path.

The core pattern

Use this structure for most work:
Example:

Source-backed review

Use this when accuracy and source traceability matter.
Good for:
  • Deviation investigations.
  • CAPA traceability.
  • Validation protocol review.
  • URS review.
  • Batch record review.
  • Regulatory or pharmacopoeia research.

Extract into a table

Use this when you need structured review.
Useful columns:

Ask for conservative drafting

Use this when language may be reviewed by QA, regulatory, or technical teams.
Variant:

Use Plan Mode before action

Use this when Sofie should think through the work first.

Create a CoDraft

For templates:

Analyze a CoSheet

Visual generation prompts

Use visual generation prompts when the answer should be easier to review as an image, chart, diagram, or illustration. Ask for chart and diagram generation when the visual should represent data, order, or relationships:
Ask for Image Generation when the visual should be illustrative:
Ask Sofie to review the result:
Formula prompt:

Use a CoMeeting

Interview prompt:

Build or run an Orchestration

Design prompt:
Run prompt:

Compare sources

Use this for regulatory, pharmacopoeia, vendor, or internal document comparisons.

Ask for a next-step workflow

What to avoid

Avoid prompts that:
  • Ask for a final conclusion without sources.
  • Include too many unrelated files.
  • Say analyze everything without an output format.
  • Ask Sofie to infer missing criteria.
  • Skip review before saving, sending, or creating a shared artifact.
Better: